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Rodent Study Suggests Hysterectomy May Affect Memory and Cognition

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Rats struggle to solve a maze after their uteruses are removed, raising questions about the impacts of the widespread procedure in humans.

(HPSN) — In medical textbooks, the nonpregnant uterus is often described as quiescent, dormant and useless. But now, researchers have found that the uterus may play a role in memory and cognition — a role hitherto unappreciated because researchers haven’t looked closely at the uterus’s role outside of pregnancy.

A third of women in the U.S. have their uteruses removed, a procedure called hysterectomy, by age 60, according to Heather Bimonte-Nelson, who directs Arizona State University’s behavioral neuroscience of memory and aging lab and is senior author of a new paper detailing the research.

The uterus is connected to the autonomic nervous system, which coordinates unconscious functions like breathing and digestion. While researchers have long studied the way the ovaries interact in the body and with the brain, the uterus has often been overlooked, according to the researchers, who studied the effects of hysterectomy in female rats.

“People talk a lot about the ovary-brain connection because we know now that estrogen and progesterone have such marked effects on things like memory. But we hope that scientists will start thinking about the uterus-ovary-brain system instead of just the ovary-brain system,” said Bimonte-Nelson.

The research team systematically tested the role of the uterus and ovaries in learning and memory in four groups each consisting of 14 or 15 rats. One group underwent a sham surgery in which no organs were removed. The remaining three groups underwent either removal of the uterus alone, removal of the ovaries alone, or removal of the uterus and the ovaries.

Holly Fitch, a professor of behavioral neuroscience at the University of Connecticut who was not involved in the research, praised the study design, saying that it used appropriate sample sizes and control groups.

The rats recovered for six weeks after their procedures, and then performed memory tests in a water maze that contained eight arms radiating out from a circular center — four arms contained hidden platforms and four arms were empty. The researchers placed the rats in the center of the maze, and once the rat found a platform it and the rat were removed. The rat then restarted the maze to search for the remaining platforms.

The test, Bimonte-Nelson said, is one that requires the rats to use their working memory. She compared it to the difference between a human remembering a phone number, which uses short-term memory, versus adding up the numbers in the phone number, which uses working memory.

Only the rats that had only their uteruses removed were unable to remember which arms of the maze never had a platform, while the other groups did remember.

The group that had both the uterus and the ovaries removed did not make as many errors as the group with only the uterus removed, indicating that the removal of the uterus alone had a unique and negative effect on working memory, or on how much information the rats could manage simultaneously, according to the researchers. The sham group and the group with only the ovaries removed performed similarly to the group with both the uterus and the ovaries removed.

The researchers were initially surprised by the results, prompting them to replicate the experiments. “When the second study results had the same effect and the same pattern was there, we knew that we had hit on something important,” Bimonte-Nelson said. “No matter how we looked at it, the data were telling us that removing the uterus was impacting cognition.”

The researchers developed the uterus and ovary removal surgeries to ensure that they were as similar to a human version of the surgery as possible, but still, results from a study looking at rats will not necessarily have the same results in humans. The researchers also noted that rat life spans are much shorter than humans’ and further research is necessary to understand if the cognitive effects of hysterectomy are long-lasting.

Furthermore, the researchers said that they don’t want the results to be alarming for women with hysterectomies, but rather a call to continue investigating the role of the uterus in cognition across the life span.

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